The Na⁺/H⁺ exchanger NHE1 is critical for cell vitality as it controls intracellular pH and cell volume. Its functionality is influenced by calcineurin B homologous proteins (CHPs). The human isoform CHP3 is important for transport of NHE1 to the plasma membrane and for its activity.

protein – protein interaction | sodium/proton exchanger | calcium-binding EF-hand protein | MO-P-030