Tau is a microtubule-associated protein (MAP) that is abundant in neurons, where it promotes the assembly and maintains the structure of microtubules. It is also found in the neurofibrillary tangles (NFT) in Alzheimer’s disease (AD). Epigallocatechin-3-gallate (EGCG) is an active phytochemical of green tea that has shown its potency against various diseases including aggregation inhibition of tau.

protein – small molecule interaction | tau | Alzheimer’s disease | MO-P-073