Mitochondrial calcium homeostasis plays a key role in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways. The mitochondrial inner membrane calcium uniporter (MCU) which mediates calcium uptake into mitochondria constitutes the pore-forming and calcium-conducting subunit of the uniporter complex (uniplex). The key regulator of mitochondrial calcium uniporter (MCUR1) which is required for calcium entry into mitochondrion, plays a direct role in uniporter-mediated calcium uptake via a direct interaction with MCU.

protein – protein interaction | membrane-bound coiled-coil protein | calcium | mitochondria | MO-P-066