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B. burgdorferi  CspA – C9 protocol

Borrelia burgdorferi is a Gram-negative bacterium that causes Lyme disease. These spirochetes are spread by ticks and if the infection is left untreated, severe and chronic symptoms develop, including neuroborreliosis, carditis and arthritis. To be able to survive in the human host, this bacterium has evolved several sophisticated mechanisms to evade the human innate immune system. One strategy is to bind complement proteins and thus inhibit the complement cascade directly. CspA is a surface exposed protein that binds the complement protein C9 and thereby blocks the complement attack and contributes to bacterial survival in the human host.

protein – protein interaction | complement evasion | MO-P-049

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