Iron–sulfur (Fe/S) clusters are essential protein cofactors crucial for many cellular functions including DNA maintenance, protein translation and energy conversion. De novo Fe/S cluster synthesis in human cells occurs on the mitochondrial scaffold protein ISCU2 and requires cysteine desulfurase NFS1, ferredoxin FDX2, frataxin FXN, and the small proteins ISD11 and ACP.

protein – protein interaction | iron-sulfur (Fe/S) clusters | mitochondrial scaffold protein | cysteine desulfurase | MO-P-029