CREB-binding protein, also known as CREBBP or CBP, is a transcriptional coactivator that carries out its function by activating transcription, where interaction with transcription factors is managed by one or more CREB domains. I-CBP112 is a small molecule inhibitor that binds to the bromodomain domain of CREBBP and has been developed for leukemia therapy.

protein – small molecule interaction | bromodomain | inhibitor | MO-P-016