DI.Control offers full flexibility in terms of plate layouts. Dilution series of ligands can be placed either in horizontal orientation (e.g. Well A1-A12) or vertical orientation (e.g. Well A1-H1, also see Vertical Plate Layouts). 

In addition, the number of dilution points can be freely selected (e.g. 8-, 12-, 16-point etc.) as well as the directionality (i.e. first well can either have lowest or highest ligand concentration). In Single-Dose assays the position of references and positive controls can be freely selected by the user. 

However, some important considerations when deciding for a specific plate layout. One of the major determinants of a plate layouts is the DilutionSeries ID, relevant for Affinity Screening or the Normalization ID, relevant for Single-Dose Screening.