Compatible solutes or osmoprotectants form a class of highly abundant organic molecules found in extremophilic bacteria. These molecules protect cells from osmotic and thermal stress by stabilizing protein and membrane structures through extensive hydration. Osmoprotectants typically accumulate in extremely high concentrations in the cell without showing any sign of toxicity or interference with metabolic pathways, making them a promising candidate for stabilization of protein-based therapeutics.

compatible solutes | osmoprotectants | thermal unfolding | conformational stability | colloidal stability | aggregation | T_m | T_on | T_agg  | PR-P-014