Heating rate dependent denaturation of p38-alpha protocol

Mitogen-activated protein kinase 14 (also called p38-α) is an enzyme that has been implicated in the regulation of many proinflammatory pathways. It is a drug target for many diseases. Thermal unfolding of p38-α at different heating rates can be used for activation energy analysis and long-term stability prediction.

thermal unfolding | heating rate | Arrhenius equation | activation energy | PR-P-008

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