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Amyloid-Beta – Protein X protocol

Amyloid-β (Aβ) is a protein involved in Alzheimer’s disease (AD) as the main component of the amyloid plaques found in the brains of people with AD. Aβ molecules can aggregate to form flexible soluble oligomers which may exist in several forms. Certain misfolded oligomers (known as ‘seeds’) can induce other Aβ molecules to also take the misfolded oligomeric form. The oligomers are toxic to nerve cells. It is unresolved how Aβ accumulates in the central nervous system and subsequently initiates the disease of cells. Finding interaction partners of e.g. Aβ is an important step in trying to find specific biological markers of disease status or disease progression. Aβ 1-42, 42-residue fragment of amyloid precursor protein, has been found to be a major constituent of the senile plaques formed in the brains of patients with Alzheimer's disease and late Down's syndrome. Aβ 1-42 readily forms neurotoxic oligomers at physiological pH. The sequence of this peptide corresponds to the sequence of human, bovine, canine, feline, ovine, guinea pig, and rabbit Aβ42.

protein – protein interaction | amyloid-beta | neurodegenerative diseases | MO-P-077

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