Dystrophin is a peripheral membrane protein, supporting the plasma membrane of muscle cells. Gene mutations lead either to a total deficit of dystrophin or to the presence of the protein in truncated forms and are responsible of Duchenne (DMD) and Becker (BMD) muscular dystrophies, respectively. Here, the authors focused on the three first spectrin-like repeats (R1-3) of dystrophin’s central domain which are known to interact with membrane lipids and are found in the potential therapeutic mini-dystrophin.

lipid – protein interaction | bicelles | lipidic target | MO-P-066