Chemokines are small molecular weight proteins which bind to and activate G-protein-coupled receptors (GPCRs) and play a crucial role in cancer cell metastasis. CCR7 is a chemokine receptor which when expressed on the surface of a cell recognizes chemokine CCL19. Interaction of chemokine CCL19 and chemokine receptor CCR7 peptides is characterized as a model system for development of peptide-based PPI inhibitors.

protein – peptide interaction | chemokine | His-tag | MO-P-064