Influenza Virus X31 – Inhibitor Coated Nanoparticle protocol
Seasonal influenza infections affect up to 15% of the human population and high mutation rates limit the use of available antiviral agents. Enveloped viruses such as influenza A bind to host cell surfaces in a multivalent binding manner. Inhibiting this multivalent binding is known to reduce the viral infection since decades. Thus, the design of such inhibitors that can inhibit this mechanism and thereby reducing the viral infection is a promising strategy in drug development. In the following, the affinity of dendritic polyglycerols (dPG) decorated with the antiviral peptide PeBGF against intact influenza A virus particles of the strain X31 was determined using MST.
virus – small molecule interaction | therapeutics | MO-P-046