tRNA is a class of RNA molecules that plays a role during the translation process – the synthesis of functional proteins. Recently, modifications of RNA molecules were shown to be linked with their biological activity. The elongator complex Elp is formed by two subcomplexes that consist of structurally arranged Elp1, Elp2, Elp3 (Elp123 subunit) and Elp4, ELp5, Elp6 (Elp456 subunit). The Elp456 subunit forms a heterohexameric ring-like structure and is involved in specific interactions with tRNA molecules.

protein – RNA interaction | elongator protein | tRNA binding | tRNA modifications | MO-P-044