Guanine quadruplex (G4) structures are higher order structures readily formed both in vitro and in vivo from single stranded guanine-rich RNA or DNA molecules. These structures are often found in the telomeric regions of chromosomes and play a regulatory role in various cellular pathways. 1H6 is a mouse monoclonal antibody which strongly binds to synthetic G4 DNA structures and can serve as a tool for detection of G4 structures in situ.

G-quadruplex DNA | antibody | stoichiometry | MO-P-043