Mitogen-activated protein kinase 14 (MAPK14, also called p38-α) is an enzyme that has been implicated in the regulation of many proinflammatory pathways. It is a drug target for many diseases such as rheumatoid arthritis, endotoxic shock and osteoporosis. SB 202190, SB 203580, SB 239063, PD 169316 and RWJ 67657 are specific and potent inhibitors of kinases that bind p38-α with low nanomolar affinity. BIRB 796 belongs to a novel class of allosteric inhibitors and binds p38-α with picomolar affinity.

protein – small molecule | kinase | inhibitor | MOX-P-100