Sirtuin 5 (also known as Sirt5) is a NAD-dependent demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups from lysine residues of target proteins. It activates carbamoyl phosphate synthetase (CPS1) and contributes to the regulation of blood ammonia levels during prolonged fasting, thereby increasing CPS1 activity in response to elevated NAD levels.

protein – small molecule interaction | deacylase | inhibitor | His-tag | MO-P-020