NanoTemper® Technologies’ PrometheusTM instruments detect changes in the fluorescence of the amino acid tryptophan (and fluorophores with equivalent spectroscopic properties) over a wide range of temperatures using nanoDSFTM, an advanced Differential Scanning Fluorimetry technology. The instruments can be used to induce thermal unfolding of proteins and to determine thermal unfolding transition temperatures. Furthermore, the instruments are equipped to investigate chemical unfolding and the free energy of unfolding ΔG in an extraordinarily straightforward and fast manner.

The PR.Stability Analysis software is dedicated to analyzing thermal and chemical unfolding data acquired with PR.ThermControl and PR.ChemControl software on Prometheus instruments. Combine any data you generated to quickly pinpoint trends and provide statistical relevance from your merged replicate data sets.