NanoTemper® Technologies’ PrometheusTM Series instruments detect changes in the fluorescence of the amino acid tryptophan (and fluorophores with equivalent spectroscopic properties) over a wide range of temperatures using nanoDSFTM, an advanced Differential Scanning Fluorimetry technology. The instruments can be used to induce thermal unfolding of proteins and to determine thermal unfolding transition temperatures. Furthermore, the instruments are equipped to investigate chemical unfolding and the free energy of unfolding ΔG in an extraordinarily straightforward and fast manner.

The PR.TimeControl software is dedicated to running and analyzing non-linear thermal unfolding and refolding experiments as well as isothermal measurements on Prometheus instruments.